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How do anabolic steroids interact with the immune system? high doses of anabolic steroids reduce the amounts of immune globulin a, g, and m in the blood. (1-4) these proteins, known medically as iga, igg, and igm, are part of. Both testosterone and anabolic androgenic steroids (aas) adversely influence the immune system, affecting leucocyte growth or activity, and antibody and cytokine production, particularly when used at supraphysiological doses, mimicking a condition of secondary immunodeficiency [ r, r ]. Steroids also reduce the activity of the immune system, which is the body's natural defence against illness and infection. This can help treat autoimmune conditions, such as rheumatoid arthritis or lupus, which are caused by the immune system mistakenly attacking the body. Abusing anabolic steroids either for the high or to build muscle will weaken your immune system, leading to more sickness and an increased risk of serious health problems. There is no way to make up for the effect that steroids can have unless you stop abusing the drugs
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